Adv Mol Med 2007; 3(4): 171-175

Published online: June 7, 2008
DOI 10.2399/amm.07.171
ORIGINAL ARTICLE

Changes in oxidative stress in Wistar albino rats during senescence

 

Makbule Aydın*, Elif Özkök*, Salih Cengiz**, Bedia Ağaçhan***, Hülya Yılmaz***, Oğuz Öztürk***, İlhan Yaylım***, Turgay İsbir***

 

*Department of Neuroscience, Institute of Experimental Medicine Research, Istanbul University, Istanbul, Turkey
**Institute of Forensic Science, Istanbul University, Istanbul, Turkey
***Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey

 

Objectives: The purpose of this study was to determine the changes in oxidative stress in Wistar albino rats during senescence.

Methods: The concentration of malondialdehyde and glutathione, which are indicators of oxidative stress, were measured in the whole brains of 3,6,12 and 24 month old Wistar albino rats.

Results: The glutathione levels of 24 months group were significantly decreased compared with those of 6 months old rats. In contrast, the malondialdehyde levels of the 24- month old group were significantly elevated compared with those of the all young groups. 

Conclusion: In conclusion, our findings have supported the hypothesis that senescence might cause increased oxidative stress

 
Key words

Glutathione (GSH), malondialdehyde (MDA), aging, brain, rat

Adv Mol Med 2007; 3(4): 171-175

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