Adv Mol Med 2007; 3(4): 165-170

Published online: June 7, 2008
DOI 10.2399/amm.07.165
REVIEW

Mannose-binding lectin in obstetrics

 

Hakan Ozan

 

Department of Obstetrics and Gynecology, Uludag University Medical Faculty, Bursa, Turkey

 

Pregnancy is a unique situation in which a fetus with paternal alloantigens can survive in a maternal environment in a state of chronic inflammation due to placentation with trophoblastic invasion and remodeling of spiral arteries. Mannose-binding lectin (MBL) plays a role in complement activation through the lectin pathway, complement-independent opsonophagocytosis, modulation of inflammation, recognition of altered self structures, removal of immune complexes, and apoptotic cell clearance. There are insufficient and conflicting data about the association between MBL and gestational complications such as miscarriage, preterm delivery, and preeclampsia. Though most reports specify the genetic expression or concentration of MBL during pregnancy, there are speculations rather than proofs regarding its role in immunopathogenesis.

 
Key words

Mannose-binding lectin, pregnancy, miscarriage, preterm delivery, preeclampsia

Adv Mol Med 2007; 3(4): 165-170

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